Microsatellite analysis for hereditary non-polyposis colorectal cancer patients

Kathy P.S. Cheung, L.P. Chung and S.T. Yuen

Department of Pathology, Queen Mary Hospital, Hong Kong


The aims of this study is to establish a radioactive method for the detection of microsatellite instability (MIN). MIN is a characteristic of mutator phenotype in Hereditary Non-Polyposis Colorectal Cancer (HNPCC). For the investigation, we use a radioactive PCR-based method by using denaturing polyacrylamide gel electrophoresis and which is a useful tool for MIN screening in diagnostic pathology.

Key words: Microsatellite. DNA mismatch repair. Hereditary non-polyposis colorectal cancer.

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