DNA Methylation, Mitotic Arrest Deficient 2 (MAD2) And Cancer - A Brief Review
Jackson Y.W. Li, W.K. Chong and Stephen T.H. Lo
Department of Pathology, Caritas Medical Centre, Hong Kong SAR, PR China.
Abstract
DNA methylation is an epigenetic mechanism in controlling gene expression which involves the control of gene promoter region. Aneuploidy is also commonly found in cancers which showed abnormal cell cycle control and cell division, partly as a consequence of abnormal spindle formation. This review aims to summarise the mechanism of DNA methylation in the promote control of gene expression of a spindle formation-controlling gene, MAD2, and its roles in breast cancer.
Keywords: Epigenetics, CpG island, DNA methylation, tumor marker, cancer therapy.
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